SPHINGOSINE-1-PHOSPHATE SECRETS

Lower concentrations of S1P are chemotactic for osteoclast precursors, even though high concentrations inhibit their motion seventy nine. This suggests that these precursors, which Categorical both S1PR1 and S1PR2, are retained while in the vicinity in the bone by the S1P gradient: S1PR2 stops S1PR1-induced migration of such bone-resorbing cells cl